SidaGhanaV1, Main, Exploration, bibRecord, 000406

A Cross-Sectional Study of ‘Yaws’ in Districts of Ghana Which Have Previously Undertaken Azithromycin Mass Drug Administration for Trachoma Control

Identifieur interne : 000406 ( Main/Exploration ); précédent : 000405; suivant : 000407

A Cross-Sectional Study of ‘Yaws’ in Districts of Ghana Which Have Previously Undertaken Azithromycin Mass Drug Administration for Trachoma Control

Auteurs : Rosanna Ghinai [Royaume-Uni] ; Philip El-Duah [Ghana] ; Kai-Hua Chi [États-Unis] ; Allan Pillay [États-Unis] ; Anthony W. Solomon [Royaume-Uni] ; Robin L. Bailey [Royaume-Uni] ; Nsiire Agana [Ghana] ; David C. W. Mabey [Royaume-Uni] ; Cheng-Yen Chen [États-Unis] ; Yaw Adu-Sarkodie [Ghana] ; Michael Marks [Royaume-Uni]

Source :

PLoS Neglected Tropical Diseases [ 1935-2727 ] ; 2015.

RBID : PMC:4310597

Descripteurs français

KwdFr :
- Adolescent, Antibactériens (usage thérapeutique), Azithromycine (usage thérapeutique), Enfant, Enfant d'âge préscolaire, Femelle, Ghana, Humains, Mâle, Pian (), Trachome (), Études transversales.
MESH :
- usage thérapeutique : Antibactériens, Azithromycine.
- Adolescent, Enfant, Enfant d'âge préscolaire, Femelle, Ghana, Humains, Mâle, Pian, Trachome, Études transversales.
Wicri :
- geographic : Ghana.

English descriptors

KwdEn :
- Adolescent, Anti-Bacterial Agents (therapeutic use), Azithromycin (therapeutic use), Child, Child, Preschool, Cross-Sectional Studies, Female, Ghana, Humans, Male, Trachoma (prevention & control), Yaws (prevention & control).
MESH :
- chemical , therapeutic use : Anti-Bacterial Agents, Azithromycin.
- geographic : Ghana.
- prevention & control : Trachoma, Yaws.
- Adolescent, Child, Child, Preschool, Cross-Sectional Studies, Female, Humans, Male.

Abstract

Yaws, caused by Treponema pallidum ssp. pertenue, is reportedly endemic in Ghana. Mass distribution of azithromycin is now the cornerstone of the WHO yaws eradication campaign. Mass distribution of azithromycin at a lower target dose was previously undertaken in two regions of Ghana for the control of trachoma. Ongoing reporting of yaws raises the possibility that resistance may have emerged in T. pallidum pertenue, or that alternative infections may be responsible for some of the reported cases. We conducted a cross-sectional survey in thirty communities in two districts of Ghana where MDA for trachoma had previously been conducted. Children aged 5–17 years with ulcerative lesions compatible with yaws were enrolled. Samples for treponemal serology and lesion PCR were collected from all children. 90 children with 98 lesions were enrolled. Syphilis serology was negative in all of them. PCR for T. pallidum ssp pertenue was negative in all children, but Haemophilus ducreyi DNA was detected in 9 lesions. In these communities, previously treated for trachoma, we found no evidence of ongoing transmission of yaws. H. ducreyi was associated with a proportion of skin lesions, but the majority of lesions remain unexplained. Integration of diagnostic testing into both pre and post-MDA surveillance systems is required to better inform yaws control programmes.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310597

DOI: 10.1371/journal.pntd.0003496
PubMed: 25632942
PubMed Central: 4310597

Affiliations:

Le document en format XML

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<wicri:regionArea>Hospital for Tropical Diseases, University College London Hospitals NHS Trust, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS Neglected Tropical Diseases</title>
<idno type="ISSN">1935-2727</idno>
<idno type="eISSN">1935-2735</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Anti-Bacterial Agents (therapeutic use)</term>
<term>Azithromycin (therapeutic use)</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Cross-Sectional Studies</term>
<term>Female</term>
<term>Ghana</term>
<term>Humans</term>
<term>Male</term>
<term>Trachoma (prevention & control)</term>
<term>Yaws (prevention & control)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Antibactériens (usage thérapeutique)</term>
<term>Azithromycine (usage thérapeutique)</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Ghana</term>
<term>Humains</term>
<term>Mâle</term>
<term>Pian ()</term>
<term>Trachome ()</term>
<term>Études transversales</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Bacterial Agents</term>
<term>Azithromycin</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>Ghana</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Trachoma</term>
<term>Yaws</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antibactériens</term>
<term>Azithromycine</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Cross-Sectional Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Ghana</term>
<term>Humains</term>
<term>Mâle</term>
<term>Pian</term>
<term>Trachome</term>
<term>Études transversales</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Ghana</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Yaws, caused by <italic>Treponema pallidum</italic>
 ssp. <italic>pertenue</italic>
, is reportedly endemic in Ghana. Mass distribution of azithromycin is now the cornerstone of the WHO yaws eradication campaign. Mass distribution of azithromycin at a lower target dose was previously undertaken in two regions of Ghana for the control of trachoma. Ongoing reporting of yaws raises the possibility that resistance may have emerged in <italic>T. pallidum</italic>
 pertenue, or that alternative infections may be responsible for some of the reported cases. We conducted a cross-sectional survey in thirty communities in two districts of Ghana where MDA for trachoma had previously been conducted. Children aged 5–17 years with ulcerative lesions compatible with yaws were enrolled. Samples for treponemal serology and lesion PCR were collected from all children. 90 children with 98 lesions were enrolled. Syphilis serology was negative in all of them. PCR for <italic>T. pallidum</italic>
 ssp <italic>pertenue</italic>
 was negative in all children, but <italic>Haemophilus ducreyi</italic>
 DNA was detected in 9 lesions. In these communities, previously treated for trachoma, we found no evidence of ongoing transmission of yaws. <italic>H. ducreyi</italic>
 was associated with a proportion of skin lesions, but the majority of lesions remain unexplained. Integration of diagnostic testing into both pre and post-MDA surveillance systems is required to better inform yaws control programmes.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Marks, M" uniqKey="Marks M">M Marks</name>
</author>
<author><name sortKey="Solomon, Aw" uniqKey="Solomon A">AW Solomon</name>
</author>
<author><name sortKey="Mabey, Dc" uniqKey="Mabey D">DC Mabey</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mitja, O" uniqKey="Mitja O">O Mitjà</name>
</author>
<author><name sortKey="Hays, R" uniqKey="Hays R">R Hays</name>
</author>
<author><name sortKey="Ipai, A" uniqKey="Ipai A">A Ipai</name>
</author>
<author><name sortKey="Penias, M" uniqKey="Penias M">M Penias</name>
</author>
<author><name sortKey="Paru, R" uniqKey="Paru R">R Paru</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Emerson, Pm" uniqKey="Emerson P">PM Emerson</name>
</author>
<author><name sortKey="Burton, Mj" uniqKey="Burton M">MJ Burton</name>
</author>
<author><name sortKey="Solomon, Aw" uniqKey="Solomon A">AW Solomon</name>
</author>
<author><name sortKey="Bailey, R" uniqKey="Bailey R">R Bailey</name>
</author>
<author><name sortKey="Mabey, Dc" uniqKey="Mabey D">DC Mabey</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Lukehart, Sa" uniqKey="Lukehart S">SA Lukehart</name>
</author>
<author><name sortKey="Godornes, C" uniqKey="Godornes C">C Godornes</name>
</author>
<author><name sortKey="Molini, Bj" uniqKey="Molini B">BJ Molini</name>
</author>
<author><name sortKey="Sonnett, P" uniqKey="Sonnett P">P Sonnett</name>
</author>
<author><name sortKey="Hopkins, S" uniqKey="Hopkins S">S Hopkins</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, X S" uniqKey="Chen X">X-S Chen</name>
</author>
<author><name sortKey="Yin, Y P" uniqKey="Yin Y">Y-P Yin</name>
</author>
<author><name sortKey="Wei, W H" uniqKey="Wei W">W-H Wei</name>
</author>
<author><name sortKey="Wang, H C" uniqKey="Wang H">H-C Wang</name>
</author>
<author><name sortKey="Peng, R R" uniqKey="Peng R">R-R Peng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Martin, Ie" uniqKey="Martin I">IE Martin</name>
</author>
<author><name sortKey="Tsang, Rsw" uniqKey="Tsang R">RSW Tsang</name>
</author>
<author><name sortKey="Sutherland, K" uniqKey="Sutherland K">K Sutherland</name>
</author>
<author><name sortKey="Tilley, P" uniqKey="Tilley P">P Tilley</name>
</author>
<author><name sortKey="Read, R" uniqKey="Read R">R Read</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Read, P" uniqKey="Read P">P Read</name>
</author>
<author><name sortKey="Jeoffreys, N" uniqKey="Jeoffreys N">N Jeoffreys</name>
</author>
<author><name sortKey="Tagg, K" uniqKey="Tagg K">K Tagg</name>
</author>
<author><name sortKey="Guy, Rj" uniqKey="Guy R">RJ Guy</name>
</author>
<author><name sortKey="Gilbert, Gl" uniqKey="Gilbert G">GL Gilbert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Asiedu, K" uniqKey="Asiedu K">K Asiedu</name>
</author>
<author><name sortKey="Amouzou, B" uniqKey="Amouzou B">B Amouzou</name>
</author>
<author><name sortKey="Dhariwal, A" uniqKey="Dhariwal A">A Dhariwal</name>
</author>
<author><name sortKey="Karam, M" uniqKey="Karam M">M Karam</name>
</author>
<author><name sortKey="Lobo, D" uniqKey="Lobo D">D Lobo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yayemain, D" uniqKey="Yayemain D">D Yayemain</name>
</author>
<author><name sortKey="King, Jd" uniqKey="King J">JD King</name>
</author>
<author><name sortKey="Debrah, O" uniqKey="Debrah O">O Debrah</name>
</author>
<author><name sortKey="Emerson, Pm" uniqKey="Emerson P">PM Emerson</name>
</author>
<author><name sortKey="Aboe, A" uniqKey="Aboe A">A Aboe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Marks, M" uniqKey="Marks M">M Marks</name>
</author>
<author><name sortKey="Chi, K H" uniqKey="Chi K">K-H Chi</name>
</author>
<author><name sortKey="Vahi, V" uniqKey="Vahi V">V Vahi</name>
</author>
<author><name sortKey="Pillay, A" uniqKey="Pillay A">A Pillay</name>
</author>
<author><name sortKey="Sokana, O" uniqKey="Sokana O">O Sokana</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mitja, O" uniqKey="Mitja O">O Mitjà</name>
</author>
<author><name sortKey="Lukehart, Sa" uniqKey="Lukehart S">SA Lukehart</name>
</author>
<author><name sortKey="Pokowas, G" uniqKey="Pokowas G">G Pokowas</name>
</author>
<author><name sortKey="Moses, P" uniqKey="Moses P">P Moses</name>
</author>
<author><name sortKey="Kapa, A" uniqKey="Kapa A">A Kapa</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Chi, K H" uniqKey="Chi K">K-H Chi</name>
</author>
<author><name sortKey="Danavall, D" uniqKey="Danavall D">D Danavall</name>
</author>
<author><name sortKey="Taleo, F" uniqKey="Taleo F">F Taleo</name>
</author>
<author><name sortKey="Pillay, A" uniqKey="Pillay A">A Pillay</name>
</author>
<author><name sortKey="Ye, T" uniqKey="Ye T">T Ye</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, C Y" uniqKey="Chen C">C-Y Chen</name>
</author>
<author><name sortKey="Chi, K H" uniqKey="Chi K">K-H Chi</name>
</author>
<author><name sortKey="Pillay, A" uniqKey="Pillay A">A Pillay</name>
</author>
<author><name sortKey="Nachamkin, E" uniqKey="Nachamkin E">E Nachamkin</name>
</author>
<author><name sortKey="Su, Jr" uniqKey="Su J">JR Su</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Orle, Ka" uniqKey="Orle K">KA Orle</name>
</author>
<author><name sortKey="Gates, Ca" uniqKey="Gates C">CA Gates</name>
</author>
<author><name sortKey="Martin, Dh" uniqKey="Martin D">DH Martin</name>
</author>
<author><name sortKey="Body, Ba" uniqKey="Body B">BA Body</name>
</author>
<author><name sortKey="Weiss, Jb" uniqKey="Weiss J">JB Weiss</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rondini, S" uniqKey="Rondini S">S Rondini</name>
</author>
<author><name sortKey="Mensah Quainoo, E" uniqKey="Mensah Quainoo E">E Mensah-Quainoo</name>
</author>
<author><name sortKey="Troll, H" uniqKey="Troll H">H Troll</name>
</author>
<author><name sortKey="Bodmer, T" uniqKey="Bodmer T">T Bodmer</name>
</author>
<author><name sortKey="Pluschke, G" uniqKey="Pluschke G">G Pluschke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Marks, M" uniqKey="Marks M">M Marks</name>
</author>
<author><name sortKey="Goncalves, A" uniqKey="Goncalves A">A Goncalves</name>
</author>
<author><name sortKey="Vahi, V" uniqKey="Vahi V">V Vahi</name>
</author>
<author><name sortKey="Sokana, O" uniqKey="Sokana O">O Sokana</name>
</author>
<author><name sortKey="Puiahi, E" uniqKey="Puiahi E">E Puiahi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ayove, T" uniqKey="Ayove T">T Ayove</name>
</author>
<author><name sortKey="Houniei, W" uniqKey="Houniei W">W Houniei</name>
</author>
<author><name sortKey="Wangnapi, R" uniqKey="Wangnapi R">R Wangnapi</name>
</author>
<author><name sortKey="Bieb, Sv" uniqKey="Bieb S">SV Bieb</name>
</author>
<author><name sortKey="Kazadi, W" uniqKey="Kazadi W">W Kazadi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thornton, Ac" uniqKey="Thornton A">AC Thornton</name>
</author>
<author><name sortKey="O Ara, Em" uniqKey="O Ara E">EM O’Mara</name>
</author>
<author><name sortKey="Sorensen, Sj" uniqKey="Sorensen S">SJ Sorensen</name>
</author>
<author><name sortKey="Hiltke, Tj" uniqKey="Hiltke T">TJ Hiltke</name>
</author>
<author><name sortKey="Fortney, K" uniqKey="Fortney K">K Fortney</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Ghana</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Grand Londres</li>
<li>Géorgie (États-Unis)</li>
<li>Région du Grand Accra</li>
</region>
<settlement><li>Accra</li>
<li>Londres</li>
</settlement>
</list>
<tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Ghinai, Rosanna" sort="Ghinai, Rosanna" uniqKey="Ghinai R" first="Rosanna" last="Ghinai">Rosanna Ghinai</name>
</region>
<name sortKey="Bailey, Robin L" sort="Bailey, Robin L" uniqKey="Bailey R" first="Robin L." last="Bailey">Robin L. Bailey</name>
<name sortKey="Bailey, Robin L" sort="Bailey, Robin L" uniqKey="Bailey R" first="Robin L." last="Bailey">Robin L. Bailey</name>
<name sortKey="Mabey, David C W" sort="Mabey, David C W" uniqKey="Mabey D" first="David C. W." last="Mabey">David C. W. Mabey</name>
<name sortKey="Mabey, David C W" sort="Mabey, David C W" uniqKey="Mabey D" first="David C. W." last="Mabey">David C. W. Mabey</name>
<name sortKey="Marks, Michael" sort="Marks, Michael" uniqKey="Marks M" first="Michael" last="Marks">Michael Marks</name>
<name sortKey="Marks, Michael" sort="Marks, Michael" uniqKey="Marks M" first="Michael" last="Marks">Michael Marks</name>
<name sortKey="Solomon, Anthony W" sort="Solomon, Anthony W" uniqKey="Solomon A" first="Anthony W." last="Solomon">Anthony W. Solomon</name>
<name sortKey="Solomon, Anthony W" sort="Solomon, Anthony W" uniqKey="Solomon A" first="Anthony W." last="Solomon">Anthony W. Solomon</name>
</country>
<country name="Ghana"><noRegion><name sortKey="El Duah, Philip" sort="El Duah, Philip" uniqKey="El Duah P" first="Philip" last="El-Duah">Philip El-Duah</name>
</noRegion>
<name sortKey="Adu Sarkodie, Yaw" sort="Adu Sarkodie, Yaw" uniqKey="Adu Sarkodie Y" first="Yaw" last="Adu-Sarkodie">Yaw Adu-Sarkodie</name>
<name sortKey="Agana, Nsiire" sort="Agana, Nsiire" uniqKey="Agana N" first="Nsiire" last="Agana">Nsiire Agana</name>
</country>
<country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Chi, Kai Hua" sort="Chi, Kai Hua" uniqKey="Chi K" first="Kai-Hua" last="Chi">Kai-Hua Chi</name>
</region>
<name sortKey="Chen, Cheng Yen" sort="Chen, Cheng Yen" uniqKey="Chen C" first="Cheng-Yen" last="Chen">Cheng-Yen Chen</name>
<name sortKey="Pillay, Allan" sort="Pillay, Allan" uniqKey="Pillay A" first="Allan" last="Pillay">Allan Pillay</name>
</country>
</tree>
</affiliations>
</record>

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Le SIDA au Ghana (serveur d'exploration)

A Cross-Sectional Study of ‘Yaws’ in Districts of Ghana Which Have Previously Undertaken Azithromycin Mass Drug Administration for Trachoma Control

A Cross-Sectional Study of ‘Yaws’ in Districts of Ghana Which Have Previously Undertaken Azithromycin Mass Drug Administration for Trachoma Control

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